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KMID : 0378019700130010056
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New Medical Journal
1970 Volume.13 No. 1 p.56 ~ p.62
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Quantitation of Immune Globulin Level of Normal Cerebrospinal Fluid in Korean
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Abstract
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With development of immunochemical methods for analysis of proteins in cerebrospinal fluid, quantitative determination of immune globulin level in cerebrospinal fluid and it´s purification have been made possible in recent years.
In 1942, Kabat and co-workers iu> , using the Tiselius 22) electrophoresis method, first reported that the cerebrospinal fluid gamma-globulin content was elevated in some patients with multiple sclerosis and s neurosyphilis.
A method of electroimmunodiffusion (RID) suitable for use with minute volumes of unconcentrated cerebrospinal fluid or other body fluid was described by Merill, et al.´s), in 1967.
The purpose of this study is to quantitate the immune globulin level of normal cerebrospinal fluid in Korean, by the method of RID.
The results are as follows: The IgG level of normal cerebrospinal fluid in Korean was 2.48+0.12 mg/ 100ml, the IgA level, 0. 27±0. 01 mg/100ml, and the mean ratio of IgG to total protein of normal cerebrospinal fluid was 6.9%.
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